|Computational models of human memory||Neural oscillatory correlates of episodic memory|
|Human spatial memory and cognition||Neural mechanisms underlying human reward learning and decision making|
| The Computational Memory Lab uses mathematical modeling and computational techniques to study human memory. We apply these quantitative methods both to data from laboratory studies of human memory and from electrophysiological studies done on patients with implanted electrodes.
Our research is focused on neurocomputational mechanisms of human episodic and spatial memory. Episodic memory refers to memory for events that are embedded in a temporal context. This includes both memory for significant life events and memory for common daily activities. In the laboratory, episodic memory is investigated by presenting lists of words for study, and then asking participants to recall the words. Using conditional probability and latency analyses (Kahana, M. J., 1996) one can quantify the way in which people transition from one recalled word to the next (see Fig. 1).
Furthermore, by studying the electrophysiology of the brain while engaged in memory tasks (as in Sederberg et al., 2007), we can find, for example, regions that show increased or decreased activity when a word is successfully encoded (i.e., later recalled) versus when it is not successfully encoded, known as the subsequent memory effect (see Fig. 2).
Computational models of human memory
To explain the processes underlying encoding, organization and retrieval of episodic memories, Kahana and colleagues (notably Marc Howard, Sean Polyn, Per Sederberg, and Lynn Lohnas) have developed a class of retrieved-context models. These models assume that the input to the memory system itself produces contextual drift, and that the current state of context is used to retrieve items from memory. The temporal context model (TCM; Howard and Kahana, 2002) was introduced to explain recency and contiguity effects in free recall. Specifically, recency effects appear because the context at the time of the memory test is most similar to the context associated with recent items. When an item is retrieved at test, it reinstates the context active when that item was studied. Because this context overlaps with the encoding context of the items' neighbors, a contiguity effect results. Consistent with experimental data, TCM and its variants also predict that recency and contiguity effects are approximately time-scale invariant (Sederberg, Howard, and Kahana, 2008). Most recently, the Context Maintenance and Retrieval model (CMR; Polyn, Norman, and Kahana, 2009) is a generalized version of TCM that accounts for non-temporal influences on recall dynamics.
Neural oscillatory correlates of episodic memory
In addition to behavioral and theoretical analyses of episodic memory, we also explore the neurophysiology of episodic memory with electrocorticographic (ECoG) and single neuron recordings from neurosurgical patients who have had electrodes surgically implanted on the cortical surface of the brain or through the medial temporal lobes (including hippocampus) as part of the clinical process of localizing seizure foci. One focus of this research is to determine the oscillatory correlates of successful episodic memory formation and retrieval. Analyses of such recordings have shown that 44-100 Hz (gamma) brain oscillations increase while participants are studying words that they will successfully, as opposed to unsuccessfully, recall (Sederberg et al., 2006). The same distribution of gamma activity across both hippocampus and neocortex is reactivated just prior to recalling an item, with higher levels of gamma predicting whether or not the recalled item was actually studied (Sederberg et al., 2007; see Fig. 2 above).
The ability to reinstate this contextual information during memory search has been considered a hallmark of episodic, or event-based, memory. In Manning et al., 2011, we sought to determine whether contextual reinstatement may be observed in electrical signals recorded from the human brain during episodic recall. We examined ECoG activity from 69 neurosurgical patients as they studied and recalled lists of words in a delayed free recall paradigm (Fig. 5A), and computed similarity between the ECoG patterns recorded just prior to each recall with those recorded after the patient had studied each word. We found that, upon recalling a studied word, the recorded patterns of brain activity were not only similar to the patterns observed when the word was studied, but were also similar to the patterns observed during study of neighboring list words, with similarity decreasing reliably with positional distance (Fig. 5C), just as predicted by context reinstatement models of free recall. The degree to which individual patients exhibited this neural signature of contextual reinstatement was correlated with the contiguity effect as seen in Fig. 5D. In this way, the study provides neural evidence for contextual reinstatement in humans.
Neural mechanisms underlying human reward learning and decision making
Recent studies in our lab have shown, for the first time, that the activity of individual neurons in the human basal ganglia are related to learning and decision making (Zaghloul et al. 2009, Zaghloul et al., in press). Through clinical collaborations, we directly recorded neural activity from single-neurons in the human basal-ganglia as participants performed a probabilistic learning and and selection task. We found that dopaminergic neurons in the substantia nigra were more active when participants received unexpected rewards compared to when they received expected rewards (Zaghloul et al. 2009). This is consistent with current theories of human reinforcement learning that implicate dopaminergic neurons in encoding prediction error, a value that increases as rewards become more surprising (Niv et al 2009). Additionally, we found that neurons in the subthalamic nucleus were more active when participants had to choose between similarly attractive options (Zaghloul et al., in press). This also is consistent with current theories of human decision making which suggest that the subthalamic nucleus plays a critical role in making difficult "high-conflict" decisions (Frank et al 2006). By studying the neural mechanisms underlying human learning and decision making, we hope lay the neurophysiological groundwork for understanding the hypothesized role of the basal ganglia in addiction and pathological reward-seeking and impulsive behavior (Hyman et al., 2006).
Human spatial memory and cognition
Our lab is also interested in the neural mechanisms underlying human spatial cognition. In this work, we use virtual reality computer games (Fig. 7) in which participants learn the locations of landmarks in virtual environments. To download a sample of a YellowCab session, click here. Using this approach, we have documented the existence and character of the 4-8 Hz theta rhythm in the human brain as participants learned to navigate through complex virtual environments (Kahana et al., 1999; Caplan et al., 2001; Caplan et al., 2003; Ekstrom et al., 2005; Jacobs et al., 2010a). Recording individual neurons during virtual navigation, we have discovered "place cells" in the human brain. These cells, which are found primarily in the human hippocampus, become active when a given spatial location is being traversed Ekstrom et al. (2003). We also identified several other cellular responses during navigation: cells that become active in response to viewing a salient landmark (from any location), cells that become active when searching for a particular goal location (irrespective of location or view), and cells that respond when traveling in a given direction (bearing/heading).
Jacobs et al. (2010b) examined recordings of single-neuron activity from neurosurgical patients playing a virtual-navigation video game. In addition to place cells, which encode the current virtual location, we describe a unique cell type, entorhinal cortex (EC) path cells, the activity of which indicates whether the patient is taking a clockwise or counterclockwise path around the virtual square road. We find that many EC path cells exhibit this directional activity throughout the environment, in contrast to hippocampal neurons, which primarily encode information about specific locations. More broadly, these findings support the hypothesis that EC encodes general properties of the current context (e.g., location or direction) that are used by hippocampus to build unique representations reflecting combinations of these properties.